If you would like to learn how to play blues guitar, there are many ways you can go about it. Assuming you have an instrument, you'll want learn the basics of strumming, simple chords, etc. With the basics, you have your choice of methods of learning. There are literally thousands of CDs, DVDs, and online lessons that will teach you how to play blues guitar. If you prefer a more hands-on method, you can search your local area for an instructor who specializes in learning Blues guitar.
Since you are specifically reading this to find out how to play Blues, you're probably already familiar with the many styles there are within the genre. Depending upon your own personal preferences, you may be more interested in acoustic guitar, which reflects the style of the early 20th century, or later generations of Blues where the electric guitar was introduced. Blues in the 1920s reflected a change with the influence and popularity of jazz.
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If you are interested in the influence that African-American women had on the Blues scene, you might want to look into recordings of Memphis Minnie - born Lizzie Douglas in 1897. On her eighth birthday, she was given a guitar, and subsequently learned how to play blues guitar and banjo. Her earliest job as a professional musician was with the Ringling Brothers Circus, where she toured during the 1910s and 1920s. Memphis Minnie's style was influenced by the Memphis Blues, which was characterized by the jug band craze of 1920s, many of which she toured with.
In addition to being recognized as the most successful female country Blues singer, she also influenced other musicians on how to play Blues guitar. Additionally, she was a musical pioneer, experimenting early on by electrifying her instrument. It wasn't until much later in the 1940s that electric guitars became standard instruments for playing this type of music. Memphis Minnie's career as a Blues artist lasted roughly forty years, until 1958, when she retired due to poor health.
How to Play Blues Guitar - The Music of Memphis Minnie